Program

This event will bring together academic and industrial experts representing many of the leading institutions in drug discovery, to discuss a selection of new and emerging topics within the fields of medicinal chemistry and related areas, and foster discussions within the wider translational science through networking and exhibitions.

Main Topics

Technologies:

PRELIMINARY PROGRAM

  • SUNDAY, JANUARY 23rd
  • MONDAY, JANUARY 24th
  • TUESDAY, JANUARY 25th
  • WEDNESDAY, JANUARY 26th

Sunday, January 23rd

16:00 - 17:30Registration
17:30 - 18:00Inauguration
18:00 - 19:00Inaugural Lecture
PL-01 José María Fernández Sousa-Faro
The sea as a source of new drugs
19:15 - 19:45SEQT Awards
20:00Welcome cocktail

Monday, January 24th

Session 1
09:00 - 09:45PL-02Rosario González
TRPM8 channel antagonists for relieving pain in chemotherapy-induced peripheral neuropathy
09:45 - 10:15KN-01José Cid
Positive allosteric modulators of GluN2B-containing NMDARs as enhancers of synaptic plasticity
10:15 - 10:45KN-02María Jesús Blanco
Leveraging endogenous metabolites for drug discovery
10:45 - 11:00OC-01SEQT 2021 Ramón Madroñero Award: Olaia Martí-Marí
Tryptophan trimers as tools for biological studies. Structure-activity relationship studies at the focal point
11:00 - 11:15OC-02Carmine Ostacolo
Design and preclinical development of CP86: A new potent in vivo antiepileptic agent
11:15 - 11:45Coffee Break
Session 2
11:45 - 12:15KN-03Santiago Vázquez
Design, synthesis, and pharmacological evaluation of soluble epoxide hydrolase inhibitors for peripheral and central inflammatory diseases
12:15 - 12:45KN-04Silvia Ortega Gutiérrez
ICMT inhibition: towards a new therapy for rapidly aging children
12:45 - 13:00OC-03Jorge Gómez-Carpintero
Flavonoid-Tacrine/Donepezil hybrids as potential MTDLs for Alzheimer’s disease
13:00 - 13:15OC-04Claudia Gioé-Gallo
Discovery and optimization of CB2R selective biased agonists for the treatment of multiple sclerosis
13:15 - 13:20FC-01Andrea L. Turcu
Design, synthesis, and in vitro and in vivo characterization of new memantine analogues for Alzheimer´s disease
13:20 - 13:25FC-02Carolina Izquierdo-García
Development of novel autophagy modulators for cancer treatment
13:25 - 13:30FC-03Carmen Viedma
Development of pharmacological tools to study the Kv4.3 channelosome in atrial fibrillation
13:30 - 15:00Monday Poster Session – Lunch (Finger-food)
15:00 - 17:15Networking Time
Session 3
17:30 - 18:00KN-05Marc Vendrell
Translational chemistry and optical imaging in humans
18:00 - 18:30KN-06Silvia Pérez
Selenium as an interesting option for the treatment of chagas disease
18:30 - 18:45OC-05Victor Vázquez-Villar
AIE effect and drug Encapsulation of poly(phenylene) chromophores for potential drug delivery
18:45 - 19:00OC-06Ainoa Sánchez-Arfelis
Development of BRD4 (BD1)-targeting molecules with computer-assisted FBDD
19:00 - 19:15OC-07Lidia Pérez-Márquez
Fluorescent molecular sensor for detection of nitrotyrosine in blood serum
19:15 - 19:30OC-08Maria Majellaro
Innovative chemistry to illuminate biology: Novel fluorescent ligands for drug discovery
19:30 - 19:35FC-04Javier García-Marín
New strategies in chronic kidney disease: A study of the ILK-Parvin protein-protein interaction towards new drugs
19:35 - 19:40FC-05Vanesa Nozal
TDP-43 modulation by selective tau tubulin kinase 1 inhibitors: A new avenue for future ALS therapy
19:40 - 19:45FC-06Alessia Bertamino
Design, synthesis, and biological evaluation of a dual acting SARS-COV-2 proteases inhibitor agent
19:45 - 20:30DEMOS/Comm Activities/Free time

Tuesday, January 25th

Session 4
09:00 - 09:45PL-03Ferrán Sanz
Data science supporting drug R&D
09:45 - 10:15KN-07Angela J. Russell
Discovery of small molecules to manipulate cell fate in vivo: Towards new therapies for degenerative diseases
10:15 - 10:45KN-08Giulia Caron
Optimizing PROTAC® technology to oral available drugs
10:45 - 11:00OC-09María Maneiro
PROTAC-antibody combinations to target breast cancer cells
11:00 - 11:15OC-10SEQT 2021 Scientific Paper Award: Sandra Codony
Synthesis, in vitro profiling, and in vivo evaluation of soluble epoxide hydrolase inhibitors for pain
11:15 - 11:45Coffee Break
Session 5
11:45 - 12:15KN-09Julio Castro-Palomino
Frontiers in medicinal chemistry: Beyond “classical” structure activity relationship
12:15 - 12:45KN-10Joaquin Pastor
Macrocyclization as a source of desired polypharmacology. Discovery of triple PI3K/mTOR/PIM inhibitors
12:45 - 13:00OC-11Toni Torrents
Collaborative & translational initiatives I
13:00 - 13:15OC-12Mabel Loza
Collaborative & translational initiatives II
13:15 - 13:30OC-13María Joao Correia
Collaborative & translational initiatives III
13:30 - 15:00Lunch. Optional visit to Innopharma facilities
Session 6
15:30 - 16:00KN-11Concepción González-Bello
Innovative strategies to unlock bacterial resistance to antibiotics
16:00 - 16:30KN-12Joaquin C Garcia Martinez
Aggregation induced emission in health applications
16:30 - 16:45OC-14Marco L. Lolli
Potent human dihydroorotate dehydrogenase inhibitors against acute myelogenous leukemia and Covid-19: From academy to clinic
16:45 - 17:00OC-15Asier Selas
REEAD assays as a DNA based sensor system for the drug screening of DNA topoisomerase 1 inhibitors
17:00 - 17:30Coffee Break
Session 7
17:30 - 17:45OC-16F. Javier Luqe
Remodelling of the conformational landscape of the Aß42 toward off-pathway aggregates
17:45 - 18:00OC-17Rafael Peláez
Ensemble pharmacophore and docking strategies for the design of new colchicine site ligands
18:00 - 18:05FC-07F. Serena Abatemateo
New red and NIR emitting fluorescent ligands with affinity for sigma-1 receptors: Tools for non-radiative biological assays
18:05 - 18:10FC-08Marta Gargantilla
XPO-1 mediated nuclear export inhibitors: Exploiting the Michael-acceptor character of chalcones
18:10 - 18:15FC-09Lourdes Acosta
Synthesis of PROTACs against CK2 an emerging antitumoral strategy
18:15 - 18:20FC-10Angel Cores
Natural product-inspired compounds obtained by a multicomponent, biologically-oriented synthesis approach and their neuroprotective profile
18:20 - 19:30Tuesday Poster Session
21:00Gala Dinner

Wednesday, January 26th

Session 8
09:00 - 09:30KN-13Ivo E. Sampaio-Dias
Melanostatin bioisosteres as modulators of the D2 receptors with application in Parkinson’s therapy
09:30 - 10:00KN-14Raquel Álvarez
Antimitotic sulfonamides as antitumor agents and leishmanicides
10:00 - 10:15OC-18Andrea Escobar-Peña
New pharmacological strategies for the treatment of resistant bacterial infections
10:15 - 10:30OC-19Manuel Pérez-Soto
Side chain and charged groups influence on naphthalene diimide DNA G-quadruplex ligands and their antiproliferative and antiparasitic activity
10:30 - 10:45OC-20Fernando Herranz
Nanomedicine for the early diagnosis of cardiovascular diseases
10:45 - 11:00OC-21Carolina Estarellas
Elucidating the selectivity for ß-isoforms of direct allosteric modulatorsof AMPK: Disclosing clues for improving drug design
11:00 - 11:05FC-12Hugo Santalla
Gemini analogues of vitamin D against colorectal cancer
11:05 - 11:10FC-13Noemí Martínez
New catechol derivatives with ß-amyloid antiaggregating effect as potential anti-Alzheimer agents
11:10 - 11:15FC-14Carlos Rodríguez-García
A magic methyl group enabled the identification of potent and subtype -selective A1AR antagonists
11:15 - 11:45Coffee Break
Session 9
11:45 - 12:15KN-15Inmaculada Fernández
Carbohydrate-based NK1 receptor antagonists as broad-spectrum anticancer agents
12:15 - 12:45KN-16Gianluca Sbardella
The long and winding road: Discovering and validating protein methyltransferase inhibitors
12:45 - 13:30PL-04Rui Moreira
Targeting Iron Metabolism Dysregulation for Precision Oncology
14:00Meeting Closing

Poster size is A0 – nominally 90 cm wide and 120 cm high, in portrait format (no landscape).

A poster number will be assigned to each abstract and will be announced to the first author.

Poster presenters are responsible for setting up and removing the posters.