This event will bring together academic and industrial experts representing many of the leading institutions in drug discovery, to discuss a selection of new and emerging topics within the fields of medicinal chemistry and related areas, and foster discussions within the wider translational science through networking and exhibitions.

Main Topics




Sunday, January 23rd

16:00 - 17:30Registration
17:30 - 18:00Inauguration
18:00 - 19:00Inaugural Lecture
PL-01 José María Fernández Sousa-Faro
The sea as a source of new drugs
19:15 - 19:45SEQT Awards
20:00Welcome cocktail

Monday, January 24th

Session 1
09:00 - 09:45PL-02Rosario González
TRPM8 channel antagonists for relieving pain in chemotherapy-induced peripheral neuropathy
09:45 - 10:15KN-01José Cid
Positive allosteric modulators of GluN2B-containing NMDARs as enhancers of synaptic plasticity
10:15 - 10:45KN-02María Jesús Blanco
Leveraging endogenous metabolites for drug discovery
10:45 - 11:00OC-01SEQT 2021 Ramón Madroñero Award: Olaia Martí-Marí
Tryptophan trimers as tools for biological studies. Structure-activity relationship studies at the focal point
11:00 - 11:15OC-02Carmine Ostacolo
Design and preclinical development of CP86: A new potent in vivo antiepileptic agent
11:15 - 11:45Coffee Break
Session 2
11:45 - 12:15KN-03Santiago Vázquez
Design, synthesis, and pharmacological evaluation of soluble epoxide hydrolase inhibitors for peripheral and central inflammatory diseases
12:15 - 12:45KN-04Silvia Ortega Gutiérrez
ICMT inhibition: towards a new therapy for rapidly aging children
12:45 - 13:00OC-03Jorge Gómez-Carpintero
Flavonoid-Tacrine/Donepezil hybrids as potential MTDLs for Alzheimer’s disease
13:00 - 13:15OC-04Claudia Gioé-Gallo
Discovery and optimization of CB2R selective biased agonists for the treatment of multiple sclerosis
13:15 - 13:20FC-01Andrea L. Turcu
Design, synthesis, and in vitro and in vivo characterization of new memantine analogues for Alzheimer´s disease
13:20 - 13:25FC-02Carolina Izquierdo-García
Development of novel autophagy modulators for cancer treatment
13:25 - 13:30FC-03Carmen Viedma
Development of pharmacological tools to study the Kv4.3 channelosome in atrial fibrillation
13:30 - 15:00Monday Poster Session – Lunch (Finger-food)
15:00 - 17:15Networking Time
Session 3
17:30 - 18:00KN-05Marc Vendrell
Translational chemistry and optical imaging in humans
18:00 - 18:30KN-06Silvia Pérez
Selenium as an interesting option for the treatment of chagas disease
18:30 - 18:45OC-05Victor Vázquez-Villar
AIE effect and drug Encapsulation of poly(phenylene) chromophores for potential drug delivery
18:45 - 19:00OC-06Ainoa Sánchez-Arfelis
Development of BRD4 (BD1)-targeting molecules with computer-assisted FBDD
19:00 - 19:15OC-07Lidia Pérez-Márquez
Fluorescent molecular sensor for detection of nitrotyrosine in blood serum
19:15 - 19:30OC-08Maria Majellaro
Innovative chemistry to illuminate biology: Novel fluorescent ligands for drug discovery
19:30 - 19:35FC-04Javier García-Marín
New strategies in chronic kidney disease: A study of the ILK-Parvin protein-protein interaction towards new drugs
19:35 - 19:40FC-05Vanesa Nozal
TDP-43 modulation by selective tau tubulin kinase 1 inhibitors: A new avenue for future ALS therapy
19:40 - 19:45FC-06Alessia Bertamino
Design, synthesis, and biological evaluation of a dual acting SARS-COV-2 proteases inhibitor agent
19:45 - 20:30DEMOS/Comm Activities/Free time

Tuesday, January 25th

Session 4
09:00 - 09:45PL-03Ferrán Sanz
Data science supporting drug R&D
09:45 - 10:15KN-07Angela J. Russell
Discovery of small molecules to manipulate cell fate in vivo: Towards new therapies for degenerative diseases
10:15 - 10:45KN-08Giulia Caron
Optimizing PROTAC® technology to oral available drugs
10:45 - 11:00OC-09María Maneiro
PROTAC-antibody combinations to target breast cancer cells
11:00 - 11:15OC-10SEQT 2021 Scientific Paper Award: Sandra Codony
Synthesis, in vitro profiling, and in vivo evaluation of soluble epoxide hydrolase inhibitors for pain
11:15 - 11:45Coffee Break
Session 5
11:45 - 12:15KN-09Julio Castro-Palomino
Frontiers in medicinal chemistry: Beyond “classical” structure activity relationship
12:15 - 12:45KN-10Joaquin Pastor
Macrocyclization as a source of desired polypharmacology. Discovery of triple PI3K/mTOR/PIM inhibitors
12:45 - 13:00OC-11Toni Torrents
Collaborative & translational initiatives I
13:00 - 13:15OC-12Mabel Loza
Collaborative & translational initiatives II
13:15 - 13:30OC-13María Joao Correia
Collaborative & translational initiatives III
13:30 - 15:00Lunch. Optional visit to Innopharma facilities
Session 6
15:30 - 16:00KN-11Concepción González-Bello
Innovative strategies to unlock bacterial resistance to antibiotics
16:00 - 16:30KN-12Joaquin C Garcia Martinez
Aggregation induced emission in health applications
16:30 - 16:45OC-14Marco L. Lolli
Potent human dihydroorotate dehydrogenase inhibitors against acute myelogenous leukemia and Covid-19: From academy to clinic
16:45 - 17:00OC-15Asier Selas
REEAD assays as a DNA based sensor system for the drug screening of DNA topoisomerase 1 inhibitors
17:00 - 17:30Coffee Break
Session 7
17:30 - 17:45OC-16F. Javier Luqe
Remodelling of the conformational landscape of the Aß42 toward off-pathway aggregates
17:45 - 18:00OC-17Rafael Peláez
Ensemble pharmacophore and docking strategies for the design of new colchicine site ligands
18:00 - 18:05FC-07F. Serena Abatemateo
New red and NIR emitting fluorescent ligands with affinity for sigma-1 receptors: Tools for non-radiative biological assays
18:05 - 18:10FC-08Marta Gargantilla
XPO-1 mediated nuclear export inhibitors: Exploiting the Michael-acceptor character of chalcones
18:10 - 18:15FC-09Lourdes Acosta
Synthesis of PROTACs against CK2 an emerging antitumoral strategy
18:15 - 18:20FC-10Angel Cores
Natural product-inspired compounds obtained by a multicomponent, biologically-oriented synthesis approach and their neuroprotective profile
18:20 - 19:30Tuesday Poster Session
21:00Gala Dinner

Wednesday, January 26th

Session 8
09:00 - 09:30KN-13Ivo E. Sampaio-Dias
Melanostatin bioisosteres as modulators of the D2 receptors with application in Parkinson’s therapy
09:30 - 10:00KN-14Raquel Álvarez
Antimitotic sulfonamides as antitumor agents and leishmanicides
10:00 - 10:15OC-18Andrea Escobar-Peña
New pharmacological strategies for the treatment of resistant bacterial infections
10:15 - 10:30OC-19Manuel Pérez-Soto
Side chain and charged groups influence on naphthalene diimide DNA G-quadruplex ligands and their antiproliferative and antiparasitic activity
10:30 - 10:45OC-20Fernando Herranz
Nanomedicine for the early diagnosis of cardiovascular diseases
10:45 - 11:00OC-21Carolina Estarellas
Elucidating the selectivity for ß-isoforms of direct allosteric modulatorsof AMPK: Disclosing clues for improving drug design
11:00 - 11:05FC-12Hugo Santalla
Gemini analogues of vitamin D against colorectal cancer
11:05 - 11:10FC-13Noemí Martínez
New catechol derivatives with ß-amyloid antiaggregating effect as potential anti-Alzheimer agents
11:10 - 11:15FC-14Carlos Rodríguez-García
A magic methyl group enabled the identification of potent and subtype -selective A1AR antagonists
11:15 - 11:45Coffee Break
Session 9
11:45 - 12:15KN-15Inmaculada Fernández
Carbohydrate-based NK1 receptor antagonists as broad-spectrum anticancer agents
12:15 - 12:45KN-16Gianluca Sbardella
The long and winding road: Discovering and validating protein methyltransferase inhibitors
12:45 - 13:30PL-04Rui Moreira
Targeting Iron Metabolism Dysregulation for Precision Oncology
14:00Meeting Closing

Poster size is A0 – nominally 90 cm wide and 120 cm high, in portrait format (no landscape).

A poster number will be assigned to each abstract and will be announced to the first author.

Poster presenters are responsible for setting up and removing the posters.