This event will bring together academic and industrial experts representing many of the leading institutions in drug discovery, to discuss a selection of new and emerging topics within the fields of medicinal chemistry and related areas, and foster discussions within the wider translational science through networking and exhibitions.

Main Topics



Sunday, June 19th

16:00 – 17:30Registration – Faculty of Medicine (USC)
17:30 – 18:00Inauguration
18:00 – 19:00Chairpersons: Beatriz de Pascual-Teresa and Eddy Sotelo

Inaugural Lecture
PL-01 José María Fernández Sousa-Faro
The sea as a source of new drugs
19:15 – 19:45SEQT Awards
20:00Welcome cocktail – Pazo de Fonseca

Monday, June 20th

Session 1

Chairpersons: Carmen Escolano and María Jesús Pérez de Vega

09:30 – 10:15PL-02Rosario González
TRPM8 channel antagonists for relieving pain in chemotherapy-induced peripheral neuropathy
10:15 – 10:45KN-01José Cid
Positive allosteric modulators of GluN2B-containing NMDARs as enhancers of synaptic plasticity
10:45 – 11:15KN-02María Jesús Blanco
Leveraging endogenous metabolites for drug discovery
11:15 – 11:30OC-01SEQT 2021 Ramón Madroñero Award: Olaia Martí-Marí
Tryptophan trimers as tools for biological studies. Structure-activity relationship studies at the focal point
11:30 – 11:45OC-02Carmine Ostacolo
Design and preclinical development of CP86: A new potent in vivo antiepileptic agent
11:45 – 12:15Coffee Break
Session 2

Chairpersons: Maria João Matos and F. Javier Luque

12:15 – 12:45KN-03Santiago Vázquez
Design, synthesis, and pharmacological evaluation of soluble epoxide hydrolase inhibitors for peripheral and central inflammatory diseases
12:45 – 13:15KN-04Silvia Ortega Gutiérrez
ICMT inhibition: towards a new therapy for rapidly aging children
13:15 – 13:30OC-03Jorge Gómez-Carpintero
Flavonoid-Tacrine/Donepezil hybrids as potential MTDLs for Alzheimer’s disease
13:30 – 13:45OC-04Claudia Gioé-Gallo
Discovery and optimization of CB2R selective biased agonists for the treatment of multiple sclerosis
13:45 – 13:50FC-01Enantia, S.A. Award: Andrea L. Turcu
Design, synthesis, and in vitro and in vivo characterization of new memantine analogues for Alzheimer´s disease
13:50 – 13:55FC-02Galchimia, S.A. Award: Carolina Izquierdo-García
Development of novel autophagy modulators for cancer treatment
13:55 – 14:00FC-03Carmen Viedma
Development of pharmacological tools to study the Kv4.3 channelosome in atrial fibrillation
14:00 – 15:45Monday Poster Session (Formal presentation for P1-01 to P1-46 & FC-01 to FC-06) – Lunch
Session 3

Chairpersons: Rodolfo Lavilla and Sara Preciado

15:45 – 16:15KN-05Marc Vendrell
Translational chemistry and optical imaging in humans
16:15 – 16:45KN-06Silvia Pérez
Selenium as an interesting option for the treatment of chagas disease
16:45 – 17:00OC-05Hugo Santalla
Gemini analogues of vitamin D against colorectal cancer
17:00 – 17:15OC-06Ainoa Sánchez-Arfelis
Development of BRD4 (BD1)-targeting molecules with computer-assisted FBDD
17:15 – 17:30OC-07Lidia Pérez-Márquez
Fluorescent molecular sensor for detection of nitrotyrosine in blood serum
17:30 – 17:45OC-08Maria Majellaro
Innovative chemistry to illuminate biology: Novel fluorescent ligands for drug discovery
17:45 – 17:50FC-04Janssen-Cilag Award: Javier García-Marín
New strategies in chronic kidney disease: A study of the ILK-Parvin protein-protein interaction towards new drugs
17:50 – 17:55FC-05Almirall, S.A. Award: Vanesa Nozal
TDP-43 modulation by selective tau tubulin kinase 1 inhibitors: A new avenue for future ALS therapy
17:55 – 18:00FC-06Alessia Bertamino
Design, synthesis, and biological evaluation of a dual acting SARS-COV-2 proteases inhibitor agent
18:00 – 18:30DEMOS/Comm Activities/Free time
18:30 – 20:00Networking Time

Tuesday, June 21st

Session 4

Chairpersons: Marta Gutiérrez and Diego Muñoz-Torrero

09:30 – 10:15PL-03Ferrán Sanz
Data science supporting drug R&D
10:15 – 10:45KN-07Angela J. Russell
Discovery of small molecules to manipulate cell fate in vivo: Towards new therapies for degenerative diseases
10:45 – 11:15KN-08Giulia Caron
Optimizing PROTAC® technology to oral available drugs
11:15 – 11:30OC-09María Maneiro
PROTAC-antibody combinations to target breast cancer cells
11:30 – 11:45OC-10Lilly Award: Sandra Codony
Synthesis, in vitro profiling, and in vivo evaluation of soluble epoxide hydrolase inhibitors for pain
11:45 – 12:15Coffee Break
Session 5

Chairpersons: Carmen Gil and Jacobo Cruces

12:15 – 12:45KN-09Julio Castro-Palomino
Frontiers in medicinal chemistry: Beyond “classical” structure activity relationship
12:45 – 13:15KN-10Joaquin Pastor
Macrocyclization as a source of desired polypharmacology. Discovery of triple PI3K/mTOR/PIM inhibitors
13:15 – 13:30OC-11Toni Torrens
Welab: Integrated Drug Discovery Platform Focused On Collaborative Translational Projects
13:30 – 14:00OC-12Mabel Loza & María João Matos
EU/ES-OPENSCREEN: Composing a unique chemical library for biological high-throughput screening
14:00 – 16:30Tuesday Poster Session (Formal presentation for P2-47 to P2-92 & FC-07 to FC-12) – Lunch
Optional visit to Innopharma facilities
Session 6

Chairpersons: Christophe Dardonville and Maria Marco

16:30 – 17:00KN-11Joaquin C Garcia Martinez
Aggregation induced emission in health applications
17:00 – 17:30KN-12Concepción González-Bello
Innovative strategies to unlock bacterial resistance to antibiotics
17:30 – 17:45OC-13Marco L. Lolli
Potent human dihydroorotate dehydrogenase inhibitors against acute myelogenous leukemia and Covid-19: From academy to clinic
17:45 – 18:00OC-14Asier Selas
REEAD assays as a DNA based sensor system for the drug screening of DNA topoisomerase 1 inhibitors
18:00 – 18:30Coffee Break
Session 7

Chairpersons:  Concepción Alonso and Eva María Priego

18:30 – 18:45OC-15F. Javier Luqe
Remodelling of the conformational landscape of the Aß42 toward off-pathway aggregates
18:45 – 19:00OC-16Rafael Peláez
Ensemble pharmacophore and docking strategies for the design of new colchicine site ligands
19:00 – 19:05FC-07F. Serena Abatemateo
New red and NIR emitting fluorescent ligands with affinity for sigma-1 receptors: Tools for non-radiative biological assays
19:05 – 19:10FC-08Marta Gargantilla
XPO-1 mediated nuclear export inhibitors: Exploiting the Michael-acceptor character of chalcones
19:10 – 19:15FC-09Lourdes Acosta
Synthesis of PROTACs against CK2 an emerging antitumoral strategy
19:15 – 19:20FC-10Noelia Carmona Zafra
Natural product-inspired compounds obtained by a multicomponent, biologically-oriented synthesis approach and their neuroprotective profile
21:00Gala Dinner – Hostal dos Reis Católicos

Wednesday, June 22nd

Session 8

Chairpersons: Bárbara Noverges and Sonia Martínez

09:30 – 10:00KN-13Ivo E. Sampaio-Dias
Melanostatin bioisosteres as modulators of the D2 receptors with application in Parkinson’s therapy
10:00 – 10:30KN-14Raquel Álvarez
Antimitotic sulfonamides as antitumor agents and leishmanicides
10:30 – 10:45OC-17Andrea Escobar-Peña
New pharmacological strategies for the treatment of resistant bacterial infections
10:45 – 11:00OC-18Manuel Pérez-Soto
Side chain and charged groups influence on naphthalene diimide DNA G-quadruplex ligands and their antiproliferative and antiparasitic activity
11:00 – 11:15OC-19Carolina Estarellas
Elucidating the selectivity for ß-isoforms of direct allosteric modulatorsof AMPK: Disclosing clues for improving drug design
11:15 – 11:20FC-11Noemí Martínez
New catechol derivatives with b-amyloid antiaggregating effect as potential anti-Alzheimer agents
11:20 – 11:25FC-12Carlos Rodríguez-García
A magic methyl group enabled the identification of potent and subtype -selective A1AR antagonists
11:25 – 12:00Coffee Break
Session 9

Chairpersons:  Beatriz de Pascual-Teresa and Maria José Camarasa

12:00 – 12:30KN-15Hugo Gutiérrez de Terán
An integrated perspective of GPCR modulation: Modeling ligand affinity, specificity and pharmacological profiles
12:30 – 13:00KN-16Gianluca Sbardella
The long and winding road: Discovering and validating protein methyltransferase inhibitors
13:00 – 13:45PL-04Rui Moreira
Targeting Iron Metabolism Dysregulation for Precision Oncology
14:00Meeting Closing

PL: Plenary Lecture | KN: Keynote |. OC: Oral communication | FC: Flash communication


Poster size is A0 – nominally 90 cm wide and 120 cm high, in portrait format (no landscape).

A poster number will be assigned to each abstract and will be announced to the first author.

Poster presenters are responsible for setting up and removing the posters.