Program
This event will bring together academic and industrial experts representing many of the leading institutions in drug discovery, to discuss a selection of new and emerging topics within the fields of medicinal chemistry and related areas, and foster discussions within the wider translational science through networking and exhibitions.
Main Topics
- Translational Medicinal Chemistry: Beyond Preliminary Optimization in Drug Discovery
- New Horizons in GPCR-Targeted Medicinal Chemistry
- Small Molecule Immunomodulators in Cancer
- Covalent Drugs & Allosteric Modulators
- Targeted Protein Degradation
Technologies:
- Expanding the Medicinal Chemistry Synthetic Toolbox
- Fluorescent-Based Tools and Screening Methods
- Target Binding Kinetics
PRELIMINARY PROGRAM
Sunday, June 19th
| 16:00 – 17:30 | Registration – Faculty of Medicine (USC) |
| 17:30 – 18:00 | Inauguration |
| 18:00 – 19:00 | Chairpersons: Beatriz de Pascual-Teresa and Eddy Sotelo Inaugural Lecture PL-01 José María Fernández Sousa-Faro The sea as a source of new drugs |
| 19:15 – 19:45 | SEQT Awards |
| 20:00 | Welcome cocktail – Pazo de Fonseca |
Monday, June 20th
Session 1 Chairpersons: Carmen Escolano and María Jesús Pérez de Vega | ||
| 09:30 – 10:15 | PL-02 | Rosario González TRPM8 channel antagonists for relieving pain in chemotherapy-induced peripheral neuropathy |
| 10:15 – 10:45 | KN-01 | José Cid Positive allosteric modulators of GluN2B-containing NMDARs as enhancers of synaptic plasticity |
| 10:45 – 11:15 | KN-02 | María Jesús Blanco Leveraging endogenous metabolites for drug discovery |
| 11:15 – 11:30 | OC-01 | SEQT 2021 Ramón Madroñero Award: Olaia Martí-Marí Tryptophan trimers as tools for biological studies. Structure-activity relationship studies at the focal point |
| 11:30 – 11:45 | OC-02 | Carmine Ostacolo Design and preclinical development of CP86: A new potent in vivo antiepileptic agent |
| 11:45 – 12:15 | Coffee Break | |
Session 2 Chairpersons: Maria João Matos and F. Javier Luque | ||
| 12:15 – 12:45 | KN-03 | Santiago Vázquez Design, synthesis, and pharmacological evaluation of soluble epoxide hydrolase inhibitors for peripheral and central inflammatory diseases |
| 12:45 – 13:15 | KN-04 | Silvia Ortega Gutiérrez ICMT inhibition: towards a new therapy for rapidly aging children |
| 13:15 – 13:30 | OC-03 | Jorge Gómez-Carpintero Flavonoid-Tacrine/Donepezil hybrids as potential MTDLs for Alzheimer’s disease |
| 13:30 – 13:45 | OC-04 | Claudia Gioé-Gallo Discovery and optimization of CB2R selective biased agonists for the treatment of multiple sclerosis |
| 13:45 – 13:50 | FC-01 | Enantia, S.A. Award: Andrea L. Turcu Design, synthesis, and in vitro and in vivo characterization of new memantine analogues for Alzheimer´s disease |
| 13:50 – 13:55 | FC-02 | Galchimia, S.A. Award: Carolina Izquierdo-García Development of novel autophagy modulators for cancer treatment |
| 13:55 – 14:00 | FC-03 | Carmen Viedma Development of pharmacological tools to study the Kv4.3 channelosome in atrial fibrillation |
| 14:00 – 15:45 | Monday Poster Session (Formal presentation for P1-01 to P1-46 & FC-01 to FC-06) – Lunch | |
Session 3 Chairpersons: Rodolfo Lavilla and Sara Preciado | ||
| 15:45 – 16:15 | KN-05 | Marc Vendrell Translational chemistry and optical imaging in humans |
| 16:15 – 16:45 | KN-06 | Silvia Pérez Selenium as an interesting option for the treatment of chagas disease |
| 16:45 – 17:00 | OC-05 | Hugo Santalla Gemini analogues of vitamin D against colorectal cancer |
| 17:00 – 17:15 | OC-06 | Ainoa Sánchez-Arfelis Development of BRD4 (BD1)-targeting molecules with computer-assisted FBDD |
| 17:15 – 17:30 | OC-07 | Lidia Pérez-Márquez Fluorescent molecular sensor for detection of nitrotyrosine in blood serum |
| 17:30 – 17:45 | OC-08 | Maria Majellaro Innovative chemistry to illuminate biology: Novel fluorescent ligands for drug discovery |
| 17:45 – 17:50 | FC-04 | Janssen-Cilag Award: Javier García-Marín New strategies in chronic kidney disease: A study of the ILK-Parvin protein-protein interaction towards new drugs |
| 17:50 – 17:55 | FC-05 | Almirall, S.A. Award: Vanesa Nozal TDP-43 modulation by selective tau tubulin kinase 1 inhibitors: A new avenue for future ALS therapy |
| 17:55 – 18:00 | FC-06 | Alessia Bertamino Design, synthesis, and biological evaluation of a dual acting SARS-COV-2 proteases inhibitor agent |
| 18:00 – 18:30 | DEMOS/Comm Activities/Free time | |
| 18:30 – 20:00 | Networking Time | |
Tuesday, June 21st
Session 4 Chairpersons: Marta Gutiérrez and Diego Muñoz-Torrero | ||
| 09:30 – 10:15 | PL-03 | Ferrán Sanz Data science supporting drug R&D |
| 10:15 – 10:45 | KN-07 | Angela J. Russell Discovery of small molecules to manipulate cell fate in vivo: Towards new therapies for degenerative diseases |
| 10:45 – 11:15 | KN-08 | Giulia Caron Optimizing PROTAC® technology to oral available drugs |
| 11:15 – 11:30 | OC-09 | María Maneiro PROTAC-antibody combinations to target breast cancer cells |
| 11:30 – 11:45 | OC-10 | Lilly Award: Sandra Codony Synthesis, in vitro profiling, and in vivo evaluation of soluble epoxide hydrolase inhibitors for pain |
| 11:45 – 12:15 | Coffee Break | |
Session 5 Chairpersons: Carmen Gil and Jacobo Cruces | ||
| 12:15 – 12:45 | KN-09 | Julio Castro-Palomino Frontiers in medicinal chemistry: Beyond “classical” structure activity relationship |
| 12:45 – 13:15 | KN-10 | Joaquin Pastor Macrocyclization as a source of desired polypharmacology. Discovery of triple PI3K/mTOR/PIM inhibitors |
| 13:15 – 13:30 | OC-11 | Toni Torrens Welab: Integrated Drug Discovery Platform Focused On Collaborative Translational Projects |
| 13:30 – 14:00 | OC-12 | Mabel Loza & María João Matos EU/ES-OPENSCREEN: Composing a unique chemical library for biological high-throughput screening |
| 14:00 – 16:30 | Tuesday Poster Session (Formal presentation for P2-47 to P2-92 & FC-07 to FC-12) – Lunch Optional visit to Innopharma facilities | |
Session 6 Chairpersons: Christophe Dardonville and Maria Marco | ||
| 16:30 – 17:00 | KN-11 | Joaquin C Garcia Martinez Aggregation induced emission in health applications |
| 17:00 – 17:30 | KN-12 | Concepción González-Bello Innovative strategies to unlock bacterial resistance to antibiotics |
| 17:30 – 17:45 | OC-13 | Marco L. Lolli Potent human dihydroorotate dehydrogenase inhibitors against acute myelogenous leukemia and Covid-19: From academy to clinic |
| 17:45 – 18:00 | OC-14 | Asier Selas REEAD assays as a DNA based sensor system for the drug screening of DNA topoisomerase 1 inhibitors |
| 18:00 – 18:30 | Coffee Break | |
Session 7 Chairpersons: Concepción Alonso and Eva María Priego | ||
| 18:30 – 18:45 | OC-15 | F. Javier Luqe Remodelling of the conformational landscape of the Aß42 toward off-pathway aggregates |
| 18:45 – 19:00 | OC-16 | Rafael Peláez Ensemble pharmacophore and docking strategies for the design of new colchicine site ligands |
| 19:00 – 19:05 | FC-07 | F. Serena Abatemateo New red and NIR emitting fluorescent ligands with affinity for sigma-1 receptors: Tools for non-radiative biological assays |
| 19:05 – 19:10 | FC-08 | Marta Gargantilla XPO-1 mediated nuclear export inhibitors: Exploiting the Michael-acceptor character of chalcones |
| 19:10 – 19:15 | FC-09 | Lourdes Acosta Synthesis of PROTACs against CK2 an emerging antitumoral strategy |
| 19:15 – 19:20 | FC-10 | Noelia Carmona Zafra Natural product-inspired compounds obtained by a multicomponent, biologically-oriented synthesis approach and their neuroprotective profile |
| 21:00 | Gala Dinner – Hostal dos Reis Católicos | |
Wednesday, June 22nd
Session 8 Chairpersons: Bárbara Noverges and Sonia Martínez | ||
| 09:30 – 10:00 | KN-13 | Ivo E. Sampaio-Dias Melanostatin bioisosteres as modulators of the D2 receptors with application in Parkinson’s therapy |
| 10:00 – 10:30 | KN-14 | Raquel Álvarez Antimitotic sulfonamides as antitumor agents and leishmanicides |
| 10:30 – 10:45 | OC-17 | Andrea Escobar-Peña New pharmacological strategies for the treatment of resistant bacterial infections |
| 10:45 – 11:00 | OC-18 | Manuel Pérez-Soto Side chain and charged groups influence on naphthalene diimide DNA G-quadruplex ligands and their antiproliferative and antiparasitic activity |
| 11:00 – 11:15 | OC-19 | Carolina Estarellas Elucidating the selectivity for ß-isoforms of direct allosteric modulatorsof AMPK: Disclosing clues for improving drug design |
| 11:15 – 11:20 | FC-11 | Noemí Martínez New catechol derivatives with b-amyloid antiaggregating effect as potential anti-Alzheimer agents |
| 11:20 – 11:25 | FC-12 | Carlos Rodríguez-García A magic methyl group enabled the identification of potent and subtype -selective A1AR antagonists |
| 11:25 – 12:00 | Coffee Break | |
Session 9 Chairpersons: Beatriz de Pascual-Teresa and Maria José Camarasa | ||
| 12:00 – 12:30 | KN-15 | Hugo Gutiérrez de Terán An integrated perspective of GPCR modulation: Modeling ligand affinity, specificity and pharmacological profiles |
| 12:30 – 13:00 | KN-16 | Gianluca Sbardella The long and winding road: Discovering and validating protein methyltransferase inhibitors |
| 13:00 – 13:45 | PL-04 | Rui Moreira Targeting Iron Metabolism Dysregulation for Precision Oncology |
| 14:00 | Meeting Closing | |
PL: Plenary Lecture | KN: Keynote |. OC: Oral communication | FC: Flash communication
Poster size is A0 – nominally 90 cm wide and 120 cm high, in portrait format (no landscape).
A poster number will be assigned to each abstract and will be announced to the first author.
Poster presenters are responsible for setting up and removing the posters.
